Topoisomerase I Inhibitor LMP400

Definition 1

An indenoisoquinoline and non-camptothecin inhibitor of topoisomerase I (Top I) with potential antineoplastic activity. Topoisomerase I inhibitor LMP400 binds to the topoisomerase I-DNA covalent cleavage complexes, and inhibits repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations. Compared to camptothecins, indenoisoquinolines are chemically stable, produce stable Top I-DNA cleavage complexes, induce unique DNA cleavage sites and appear more resistant to multidrug efflux pumps. (NCI Thesaurus)

Definition 2

A substance being studied in the treatment of cancer. It blocks certain enzymes that break and rejoin DNA strands. These enzymes are needed for cells to divide and grow. Blocking them may cause cancer cells to die. LMP400 also helps anticancer drugs kill cancers that are resistant to some other drugs. LMP400 is a type of indenoisoquinoline and a type of topoisomerase inhibitor. (NCI Dictionary)

YOU MAY ALSO LIKE

Topoisomerase I Inhibitor Genz-644282

A non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Topoisomerase I inhibitor Genz-644282 binds to and inhibits the enzyme topoisomerase I,…

Topoisomerase I

DNA topoisomerase I (765 aa, ~91 kDa) is encoded by the human TOP1 gene. This protein plays a role in the regulation…

Topoisomerase

Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand…

Topography

The description of an anatomical region or of a body part.

Topogram

A 2D projected image from a tomographic device that does not utilize its full capability of reconstructing into slices.

Topixantrone

A 9-aza-anthrapyrazole antineoplastic antibiotic. Topixantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as…