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Topotecan hydrochloride
Pronunciation
Definition 1
A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Topotecan hydrochloride is a type of topoisomerase inhibitor. Also called Hycamtin and topotecan. (NCI Dictionary)
Definition 2
The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. (NCI Thesaurus)
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