Total Clearance Observed Normalized by Surface Area

Definition 1

The observed total body clearance for intravascular administration divided by the surface area. (NCI Thesaurus)

Definition 2

The total body clearance for intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the surface area. (NCI Thesaurus/CDISC)

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The observed total body clearance for extravascular administration based on the fraction of dose absorbed and divided by the dose.

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