TPMT*3C Allele

Human TPMT*3C allele is located in the vicinity of 6p22.3 and is approximately 26 kb in length. This allele, a variant form of the TPMT wild-type allele, encodes thiopurine S-methyltransferase protein. TPMT*3C allele exhibits a clinically-relevant SNP (c.874A>G) that results in an Y240C coding change. This alteration in protein sequence decreases the enzymatic activity of the protein encoded by this allelic variant. (NCI Thesaurus)

YOU MAY ALSO LIKE

TPMT*3A Allele

Human TPMT*3A allele is located in the vicinity of 6p22.3 and is approximately 26 kb in length. This allele, a variant form…

TPMT*2 Allele

Human TPMT*2 allele is located in the vicinity of 6p22.3 and is approximately 26 kb in length. This allele, a variant form…

TPMT wt Allele

Human TPMT wild-type allele is located in the vicinity of 6p22.3 and is approximately 26 kb in length. This allele, which encodes…

TPMT Gene

This gene plays a role in the metabolism of thiopurine drugs.

TPM4/ALK Fusion Protein

A fusion protein encoded by the TPM4/ALK fusion gene. This protein is comprised of most of the tropomyosin alpha-4 chain protein fused…

TPM4/ALK Fusion Gene

A fusion gene that results from a chromosomal translocation t(1;2)(q25;p23) which fuses most of the coding sequence of the TPM4 gene to…