TPR/MET Fusion Gene

A fusion gene (~2.0 kb) that results from a chromosomal rearrangement involving chromosomes 1 and 7 that fuses the 5' portion of the TPR gene to the 3' portion of the MET gene. This fusion gene is associated with gastric carcinoma and other cancers. (NCI Thesaurus)

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TPR wt Allele

Human TPR wild-type allele is located in the vicinity of 1q25 and is approximately 64 kb in length. This allele, which encodes…

TPR Gene

This gene plays a role in both nuclear transport and mitosis.

TPO wt Allele

Human TPO wild-type allele is located within 2p25 and is approximately 129 kb in length. This allele, which encodes thyroid peroxidase protein,…

TPO Signaling Pathway

Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through several major…

TPO Receptor Agonist ONO-7746

An orally available small molecule and platelet thrombopoietin (TPO) receptor (TPOR; MPL) agonist with potential megakaryopoiesis stimulating activity. Upon administration, TPOR agonist…

TPO Gene

This gene is involved in thyroid hormone biosynthesis.