TPR/MET Fusion Protein

A fusion protein (523 aa, ~60 kDa) encoded by the TPR/MET fusion gene. This protein is comprised of approximately 140 N-terminal amino acids of the nucleoprotein TPR, including two leucine zipper motifs, fused to the intracellular tyrosine kinase domain of the hepatocyte growth factor receptor protein. (NCI Thesaurus)

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TPR/MET Fusion Gene

A fusion gene (~2.0 kb) that results from a chromosomal rearrangement involving chromosomes 1 and 7 that fuses the 5' portion of…

TPR wt Allele

Human TPR wild-type allele is located in the vicinity of 1q25 and is approximately 64 kb in length. This allele, which encodes…

TPR Gene

This gene plays a role in both nuclear transport and mitosis.

TPO wt Allele

Human TPO wild-type allele is located within 2p25 and is approximately 129 kb in length. This allele, which encodes thyroid peroxidase protein,…

TPO Signaling Pathway

Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through several major…

TPO Receptor Agonist ONO-7746

An orally available small molecule and platelet thrombopoietin (TPO) receptor (TPOR; MPL) agonist with potential megakaryopoiesis stimulating activity. Upon administration, TPOR agonist…