TPR/NTRK1 Fusion Gene TRKT1

A fusion gene (~1.7 kb) that results from an inversion of on the q arm of chromosome 1 that fuses 598 nucleotides from the 5' end of the TPR gene to 1148 nucleotides from the 3' portion of the NTRK1 gene. This rearrangement is associated with papillary thyroid carcinoma. (NCI Thesaurus)

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A fusion protein (523 aa, ~60 kDa) encoded by the TPR/MET fusion gene. This protein is comprised of approximately 140 N-terminal amino…

TPR/MET Fusion Gene

A fusion gene (~2.0 kb) that results from a chromosomal rearrangement involving chromosomes 1 and 7 that fuses the 5' portion of…

TPR wt Allele

Human TPR wild-type allele is located in the vicinity of 1q25 and is approximately 64 kb in length. This allele, which encodes…

TPR Gene

This gene plays a role in both nuclear transport and mitosis.

TPO wt Allele

Human TPO wild-type allele is located within 2p25 and is approximately 129 kb in length. This allele, which encodes thyroid peroxidase protein,…

TPO Signaling Pathway

Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through several major…