| Health / Medical Topics |
TPR wt Allele
Human TPR wild-type allele is located in the vicinity of 1q25 and is approximately 64 kb in length. This allele, which encodes nucleoprotein TPR, is involved in the regulation of both the mitotic spindle checkpoint and nuclear pore transport. Chromosomal rearrangement of this gene and the MET gene is associated with gastric cancer and rearrangement of this gene and the NTRK1 gene is associated with papillary thyroid carcinoma. (NCI Thesaurus)
YOU MAY ALSO LIKE
This gene plays a role in both nuclear transport and mitosis.
Human TPO wild-type allele is located within 2p25 and is approximately 129 kb in length. This allele, which encodes thyroid peroxidase protein,…
Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through several major…
An orally available small molecule and platelet thrombopoietin (TPO) receptor (TPOR; MPL) agonist with potential megakaryopoiesis stimulating activity. Upon administration, TPOR agonist…
This gene is involved in thyroid hormone biosynthesis.
A substance made by the body that helps make blood cells, especially platelets. A form of TPO made in the laboratory is…
