| Health / Medical Topics |
TRADD Protein
TRADD is an adaptor protein involved in the recruitment of FADD or TRAF signaling proteins into TNF-stimulated cell death or NFKB induction. TRADD contains a death domain, similar to that of TNFR1, capable of mediating TRADD oligomerization, interaction with the TNFR1 death domain, stimulation of apoptosis, and NFKB activation. TNF-induced apoptosis involves TRADD-mediated ICE cysteine protease activation. NFKB activation by TRADD involves a different pathway. (from J Leukoc Biol 1998. 63:678, OMIM 603500, and NCI) (NCI Thesaurus)
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