Transferrin Receptor

Definition 1

Homodimeric human Transferrin Receptors (M28B Peptidase Family) are type II membrane proteins involved in the cellular import of transferrin-bound iron and appear necessary for iron metabolism, cell function, and erythrocyte differentiation. (NCI Thesaurus)

Definition 2

Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released. (NLM, Medical Subject Headings)

Definition 3

major vehicle for cellular uptake of iron; receptor expression is tightly regulated by available iron, via an "iron-responsive element" (IRE) on its mRNA which prevents translation when occupied by an iron- sensitive binding protein. (NIH CRISP Thesaurus)

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