Transferrin Receptor 1

Regulated by mitogenic stimulation and cellular iron levels (through IRP1/2), TFRC Gene (M28B Peptidase Family) encodes 760-aa 85-kDa Transferrin Receptor 1, a glycosylated, phosphorylated, and palmitoylated type II membrane disulfide-linked homodimeric glycoprotein involved in cellular uptake of iron via receptor-mediated endocytosis. After intracellular iron release, apotransferrin-receptor is recycled to the cell surface with release of apotransferrin. Transferrin receptor appears necessary for nervous system and erythrocyte development, binds HLA class II histocompatibility antigen DR1, and binds parvoviruses that enter and infect cells. Ligand HFE competes with transferrin for binding to an overlapping C-terminal site. Proteolytic cleavage at Arg100 produces the glycosylated secreted sTfR isoform; used in a diagnostic test for anemia. (NCI Thesaurus)

YOU MAY ALSO LIKE

Transferrin Receptor

Homodimeric human Transferrin Receptors (M28B Peptidase Family) are type II membrane proteins involved in the cellular import of transferrin-bound iron and appear…

Transferrin Measurement

The determination of the amount of transferrin present in a sample.

Transference

The displacement of activities or cognitive content from one area to another.

Transferase Gene

Transferase Genes encode enzymes (Transferases) that transfer a group, such as a methyl group or a glycosyl group, from one compound (donor)…

Transferase Deficiency Galactosemia

A disorder characterized by the body's inability to metabolize galactose. This type of galactosemia is caused by germline mutations in the GALT…

Transferase

Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor)…