Health / Medical Topics |
Translation Initiation Abnormality
An abnormality that results from a functional change in the mRNA sequence at the translation initiation codon. In eukaryotic organisms, the initiation codon is always AUG. A mutation in either DNA or corresponding mRNA that alters this initiation sequence causes termination of mRNA translation. No functional protein product is synthesized when a translation initiation abnormality exists. (NCI Thesaurus)
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