Trefoil Factor 1

Definition 1

Trefoil factor 1 (84 aa, ~9 kDa) is encoded by the human TFF1 gene. This protein is involved in the maintenance of the gastrointestinal mucosa. (NCI Thesaurus)

Definition 2

Encoded by human TFF1 Gene (Trefoil Family), 84-amino acid 9 kD (precursor) Trefoil Protein 1 (one trefoil domain) is expressed in stomach and duodenum. Trefoil proteins are stable secretory polypeptides expressed in gastrointestinal mucosa that have at least one trefoil motif (P-type domain), a 40-amino acid domain containing three conserved disulfides, and may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. The exact function has not been determined, but TFF1 may participate in gastrointestinal cell differentiation by delaying G1/S transition and reducing apoptosis. Strong expression is also found in the regenerative tissues surrounding ulcerous lesions of the gastrointestinal tract. (from Swiss-Prot P04155, OMIM 113710, and NCI) (NCI Thesaurus)

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