Health / Medical Topics

    Treosulfan

    Pronunciation

    Definition 1

    A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called alkylating agents. (NCI Dictionary)

    Definition 2

    The prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppressive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhibits myeloablative and immunosuppressive activities. (NCI Thesaurus)




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