| Health / Medical Topics |
Triazinate
A synthetic dihydrotriazine derivative with antineoplastic properties. As an antifolate agent related to methotrexate (MTX), triazinate inhibits the enzyme dihydrofolate reductase (DHFR), resulting in decreased tetrahydrofolate production and interference with thymidylate synthesis. Unlike MTX, this agent is not converted to polyglutamate forms. Triazinate also inhibits the transport of folates and may be selectively toxic to MTX-resistant tumor cells. (NCI Thesaurus)
YOU MAY ALSO LIKE
A synthetic triazene derivative with antineoplastic activity. Upon metabolic activation via N-demethylation, TriN2755 is converted into highly reactive carbocations that can alkylate…
Any of a class of organic compounds having an amine directly attached to an azo group. Triazene compounds act as alkylating agents…
A substance being studied in the treatment of cancer. It is a type of ribonucleotide reductase inhibitor. Also called 3-aminopyridine-2-carboxaldehyde thiosemicarbazone and…
Human TRIAP1 wild-type allele is located in the vicinity of 12q24.31 and is approximately 2 kb in length. This allele, which encodes…
This gene is involved in the inhibition of apoptosis.
The pelvic layer separating the deep perineal space from the upper pelvis.
