Triphenylethylene

the core chemical structure of a number of related anti-estrogen compounds. The triphenylethylene antiestrogens, which include idoxifene, toremifene, chlorotrianisene, raloxifene and tamoxifen, act at the level of the estrogen receptor, triggering inhibition or stimulation of estrogen-dependent gene transcription and cellular physiology. Triphenylethylenes were initially developed for the treatment of estrogen-dependent breast cancers. Selective estrogen receptor modulators (SERMs) such as raloxifene and tamoxifen represent triphenylethylene derivatives that affect transcriptional regulation through modulation of specific alpha and beta estrogen receptors that are differentially expressed in various normal and neoplastic tissues. (NCI Thesaurus)

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Triphasic

Occurring in or characterized by three phases or stages.

Tripelennamine Hydrochloride

The hydrochloride salt form of tripelennamine, an ethylenediamine derivative with an antihistaminergic property. Tripelennamine hydrochloride competitively blocks central and peripheral histamine H1…

Tripartite Motif-Containing Protein 5

Tripartite motif-containing protein 5 (493 aa, ~56 kDa) is encoded by the human TRIM5 gene. This protein plays a role in the…

Tripartite Motif-Containing Protein 16

Tripartite motif-containing protein 16 (564 aa, ~64 kDa) is encoded by the human TRIM16 gene. This protein is involved in histone acetylation,…

TRIP12 wt Allele

Human TRIP12 wild-type allele is located in the vicinity of 2q36.3 and is approximately 155 kb in length. This allele, which encodes…

TRIP12 Gene

This gene may be involved in ubiquitination.