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Troxacitabine
Pronunciation
Definition 1
A drug being studied for use as an anticancer agent. (NCI Dictionary)
Definition 2
A dioxolane derivative and a novel L-configuration deoxycytidine analogue with potent antineoplastic activity. When incorporated into growing chain during DNA replication, troxacitabine stops DNA polymerization due to its unnatural L-configuration, in contrast to the normal nucleotides with D-configuration. As a result, this agent terminates DNA synthesis upon incorporated into DNA molecules, and consequently interrupts tumor cell proliferation. (NCI Thesaurus)
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The trough concentration divided by dose.
The trough concentration divided by body mass index.
Concentration at end of dosing interval.
