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TTI-237
Definition 1
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called mitotic inhibitors. (NCI Dictionary)
Definition 2
A small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. TTI-237 stabilizes tubulin and inhibits microtubule disassembly. This results in cell cycle arrest at the G2/M phase, and leading to cell death. (NCI Thesaurus)
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