Tuberin

Tuberin has sequence similarity to the GTPase-activating protein GAP3 and may regulate cell growth. It specifically stimulates the GTPase activity of RAS-related RAP1A protein, but not of RAP2, H, RAC, or RHO. Tuberin exhibits GAP activity (mediated by rabaptin-5) towards RAB5, a critical docking and fusion component of the endocytic pathway. (from OMIM 191092 and NCI) (NCI Thesaurus)

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