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Tumor Necrosis Factor Ligand Superfamily Member 10
Definition 1
Tumor Necrosis Factor Ligand Superfamily Member 10, encoded by the TNFSF10 Gene, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of cells. It preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. (From LocusLink, OMIM and NCI) (NCI Thesaurus)
Definition 2
A cell protein that can attach to certain molecules in some cancer cells and may kill the cells. Apo-2L is being studied in the treatment of cancer. (NCI Dictionary)
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