| Health / Medical Topics |
Tumor Necrosis Factor Ligand Superfamily Member 15
Vascular Endothelial Growth Inhibitor is a TNF-related type II transmembrane protein, with an extracellular C-terminus, a single transmembrane domain, and a short cytoplasmic tail. VEGI is expressed as multiple mRNAs in most tissues, arterial endothelial cells, and monocytes, but not in B- or T-cells. Soluble VEGI markedly reduces vascularization and inhibits the growth of aortic endothelial cells and colon carcinomas. VEGI appears to be an angiogenesis inhibitor that directly inhibits endothelial cell proliferation. VEGI appears to cause endothelial cell apoptosis by activation of the SAPK/JNK stress protein kinases, p38 MAPK, and caspase-3. (from OMIM 604052 and NCI) (NCI Thesaurus)
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