Tumor Necrosis Factor Ligand Superfamily Member 6

FAS ligand is a TNF family, type II transmembrane protein expressed on many cell types and secreted from T-cells upon TCR ligation by MHC/peptide complexes residing on antigen presenting cells. FAS ligand triggers cell death by binding to the cell surface receptor FAS, another transmembrane protein member of the TNF receptor family. FAS ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T-cell-mediated cytotoxicity, and in the liver, lung, ovary, and heart, where its function is unclear. (from OMIM 134638 and NCI) (NCI Thesaurus)

YOU MAY ALSO LIKE

Tumor Necrosis Factor Ligand Superfamily Member 4

OX40 ligand is a type II membrane protein and member of the tumor necrosis factor family. OX40L interaction with its receptor…

Tumor Necrosis Factor Ligand Superfamily Member 15

Vascular Endothelial Growth Inhibitor is a TNF-related type II transmembrane protein, with an extracellular C-terminus, a single transmembrane domain, and a short…

Tumor Necrosis Factor Ligand Superfamily Member 13B

Tumor necrosis factor ligand superfamily member 13B (285 aa, ~31 kDa) is encoded by the human TNFSF13B gene. This protein is involved…

Tumor Necrosis Factor Ligand Superfamily Member 13

Tumor necrosis factor ligand superfamily member 13 (250 aa, ~27 kDa) is encoded by the human TNFSF13 gene. This protein is involved…

Tumor Necrosis Factor Ligand Superfamily Member 11

Most highly expressed in lymph nodes and upregulated by TCR stimulation, human TNFSF11 Gene (TNF Family) encodes alternative isoforms of 35-kDa (precursor)…

Tumor Necrosis Factor Ligand Superfamily Member 10

Tumor Necrosis Factor Ligand Superfamily Member 10, encoded by the TNFSF10 Gene, is a homotrimeric type II membrane protein that rapidly induces…