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Tumor suppressor gene
Pronunciation
Definition 1
A type of gene that makes a protein called a tumor suppressor protein that helps control cell growth. Mutations (changes in DNA) in tumor suppressor genes may lead to cancer. Also called antioncogene. (NCI Dictionary)
Definition 2
Tumor Suppressor Genes encode proteins whose functions inhibit expression of tumorigenic phenotypes by holding cellular proliferation in check. When inactivated or lost, a barrier to normal proliferation is removed and deregulated growth is possible. (NCI Thesaurus)
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Colony-forming cells which give rise to neoplasms.
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