| Health / Medical Topics |
Tumor Suppressor Gene Inactivation Process
Any DNA sequence alteration process occurring in a tumor suppressor gene, resulting in loss of function of the gene product, and predisposing the cell to neoplastic transformation. Tumor suppressor genes are ordinarily involved in repressing cell cycle or promoting apoptosis. Inactivation of such genes permits growth inappropriately, and is an important step in the process of cellular transformation. (NCI Thesaurus)
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A type of gene that makes a protein called a tumor suppressor protein that helps control cell growth. Mutations (changes in DNA)…
Tumor suppressor candidate 4 protein (380 aa, ~44 kDa) is encoded by the human TUSC4 gene. This protein may play a role…
Tumor suppression involves inhibition of tumor cell growth, proliferation, malignancy, or metastasis.
Expressed predominantly in fetal and adult liver and kidney by human SLC22A1L Gene (Polyspecific Transporter/MDR Family), 424-aa Tumor Suppressing Subtransferable Candidate 5…
Encoded by human TSSC1 Gene, 387-amino acid 44 kD Tumor Suppressing Subtransferable Candidate 1 Protein is similar to Rb-Associated Protein p48 and…
Colony-forming cells which give rise to neoplasms.
