Tyroserleutide

A tripeptide consisting of tyrosine, serine, and leucine with potential antineoplastic activity. Although the mechanism of its antitumor activity has yet to be fully elucidated, tyroserleutide appears to inhibit the expression of ICAM-1 (CD54), a cell adhesion factor of the immunoglobulin (Ig) superfamily that plays an important role in the invasion, adhesion, and metastasis of tumor cells. In addition, this agent may influence the Ca2+/calmodulin pathway, inhibiting phosphatidylinositol 3 kinase (PI3K); PI3K is upregulated in tumor cells and is involved in cellular proliferation. (NCI Thesaurus)

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TYROBP wt Allele

Human TYROBP wild-type allele is located in the vicinity of 19q13.1 and is approximately 4 kb in length. This allele, which encodes…

TYROBP Gene

This gene plays a role in signal transduction for a variety of cellular processes.

TYRO3 wt Allele

Human TYRO3 wild-type allele is located within 15q15.1-q21.1 and is approximately 20 kb in length. This allele, which encodes tyrosine-protein kinase receptor…

TYRO3 Gene

This gene plays a role in tyrosine phosphorylation signal transduction, and has been implicated in cellular adhesion processes.

TYRO Protein Tyrosine Kinase Binding Protein

TYRO protein tyrosine kinase-binding protein (113 aa, ~12 kDa) is encoded by the human TYROBP gene. This protein is involved in the…

Tyrer-Cuzick Model

A breast cancer risk model that incorporates both genetic and nongenetic factors. It uses a combination of extensive family history, endogenous estrogen…