Tyrosine Phosphatase SHP Substrate-1

Encoded as 3 isoforms by human PTPNS1 Gene (SIRP/Ig Families), ubiquitous (high in brain) N-glycosylated Tyrosine Phosphatase SHP Substrate 1 is a type I membrane protein cell surface CD47 receptor that contains an Ig-V-type and 2 Ig-C1-type domains. A negative receptor tyrosine kinase regulator to cell adhesion, growth factors, or insulin and phosphorylated by receptor signal transduction, PTPNS1 recruits SH2 domain PTPs as signaling PTP substrates. PTPNS1 induces membrane translocation of PTPN6, -11, and other cytosolic partners; negatively regulates phagocytosis, mast cell activation, and dendritic cell activation/maturation; and regulates neural adhesion, neurite outgrowth, glial attachment, synaptogenesis, and synaptic function. Dephosphorylated by PTPN11 (PTPN6 in macrophages), PTPNS1 appears to bind GRB2, PTK2B, and FGR; forms a stable complex with JAK2; and binds SCAP1/SCAP2, recruiting FYB. (NCI Thesaurus)

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