UBC Domain

The 16-kD UBC domain contains a conserved UBC motif and a conserved cysteine that accepts activated ubiquitin from E1 enzyme to form a thiol ester. Basic residues at the UBC domain N-terminus may be involved in E1 binding. UBC/E2 enzymes catalyze ubiquitination of target proteins with or without E3 'N-end' recognizing proteins. E2s can be classified on the basis of UBC structure. Poor at transferring ubiquitin to proteins on their own, Class I proteins comprise simply the UBC domain and probably require an E3 to ubiquitinate short-lived abnormal proteins prior to degradation. Class II enzymes contain different acidic C-terminal extensions of the UBC domain that appear to involve cellular localization or to mediate interaction with protein substrates for ubiquitination that results in protein modification but not degradation. Class III E2s have N-terminal extensions, but their function is unknown. (NCI Thesaurus)

YOU MAY ALSO LIKE

UBB wt Allele

Human UBB wild-type allele is located within 17p12-p11.2 and is approximately 2 kb in length. This allele, which encodes ubiquitin protein, plays…

UBB Gene

This gene is involved in ubiquitin-dependent proteolysis.

UBASH3B wt Allele

Human UBASH3B wild-type allele is located in the vicinity of 11q24.1 and is approximately 159 kb in length. This allele, which encodes…

UBASH3B Gene

This gene plays a role in the dephosphorylation of protein kinases.

UBA3 wt Allele

Human UBA3 wild-type allele is located within 3p24.3-p13 and is approximately 26 kb in length. This allele, which encodes NEDD8-activating enzyme E1…

UBA3 Gene

This gene is involved in post-translational protein modification.