Ubenimex

A microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Aminopeptidases has been implicated in the process of cell adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte, macrophage and bone marrow stem cell as well as stimulates release of interleukin-1 and -2, thus further enhances its antitumor activity. (NCI Thesaurus)

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UBE4B wt Allele

Human UBE4B wild-type allele is located in the vicinity of 1p36.3 and is approximately 148 kb in length. This allele, which encodes…

UBE4B Gene

This gene plays a role in polyubiquitination.

UBE3A wt Allele

Human UBE3A wild-type allele is located within 15q11-q13 and is approximately 102 kb in length. This allele, which encodes ubiquitin-protein ligase E3A,…

UBE3A Gene

This gene is involved in protein turnover.

UBE2L3 wt Allele

Human UBE2L3 wild-type allele is located in the vicinity of 22q11.2 and is approximately 75 kb in length. This allele, which encodes…

UBE2L3 Gene

This gene plays a role in protein ubiquitination.