Vascular Endothelial Growth Factor Antisense Oligonucleotide

Definition 1

An antisense oligonucleotide with potential antiangiogenesis activity. Vascular endothelial growth factor (VEGF) antisense oligonucleotide binds directly to binds VEGF A/C/D mRNA, leading to mRNA degradation and the inhibition of VEGF A-mediated angiogenesis and VEGF C/D-mediated lymphangiogenesis. (NCI Thesaurus)

Definition 2

A substance that has been studied in the treatment of cancer. It binds to the RNA for a protein called vascular endothelial growth factor (VEGF) that stimulates the growth of new blood vessels. Vascular endothelial growth factor-antisense oligonucleotide blocks the cell's ability to make VEGF, which may kill tumors that need new blood vessels to grow. It is a type of antisense oligonucleotide and a type of gene expression inhibitor. (NCI Dictionary)

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