| Health / Medical Topics |
VAV1 Protein
VAV1 protein is a proto-oncogene product with features of a transcription factor, including an N-terminal acidic region, a proline-rich region, and two zinc finger-like domains. VAV also has an SH2, two SH3, and a guanosine exchange factor domain. Truncation of its N-terminus, containing an HLH domain and leucine zipper, activates its oncogenic potential. Wild type VAV is transcribed in hematopoietic cells, including erythroid, lymphoid, and myeloid lineages. VAV-dependent signaling pathways regulate the maturation of T-cells. (from OMIM 164875 and NCI) (NCI Thesaurus)
YOU MAY ALSO LIKE
This gene plays a role in signal transduction. It is involved in the development and activation of both B cells and T…
VAV Family Genes (VAV1, VAV2, and VAV3) encode VAV proteins that respond to similar cell surface receptor tyrosine kinases as GEFs for…
A specialized bulblike nerve ending located in the subcutaneous tissue of the skin; occurs abundantly in the skin of palms and soles…
The succinate salt of vatalanib, an anilinophthalazine derivative, with antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of…
A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called protein tyrosine kinase…
The largest muscle in the quadriceps femoris that is responsible for extending and stabilizing the knee.
