| Health / Medical Topics |
VAV2 Protein
A member of the VAV oncogene family, VAV2 is a probable exchange factor for a RAS-like GTP-binding protein and responds to a cell surface receptor tyrosine kinase. Integrin-induced phosphorylation of VAV2 requires SYK. VAV2 contains a calponin-homology domain, a DBL-homology domain, a PH domain, a DAG binding domain, an SH2 domain, and SH3 domains. (from OMIM 600428 and NCI) (NCI Thesaurus)
YOU MAY ALSO LIKE
This gene plays a role in signal transduction and negative regulation of T-cell activation.
Human VAV1 wild type allele is located in the vicinity of 19p13.2 and is approximately 85 kb in length. This allele, which…
VAV1 protein is a proto-oncogene product with features of a transcription factor, including an N-terminal acidic region, a proline-rich region, and two…
This gene plays a role in signal transduction. It is involved in the development and activation of both B cells and T…
VAV Family Genes (VAV1, VAV2, and VAV3) encode VAV proteins that respond to similar cell surface receptor tyrosine kinases as GEFs for…
A specialized bulblike nerve ending located in the subcutaneous tissue of the skin; occurs abundantly in the skin of palms and soles…
