VAV3 Protein

Encoded by human VAV3 Gene (VAV Family), the 847-amino acid VAV-3 Protein exhibits similarity to VAV1 and VAV2. Alpha and beta isoforms are expressed in peripheral blood lymphocytes, spleen, brain, thymus, heart, kidney, liver, placenta, and lung. VAV3 contains DBL and pleckstrin homology domains, a calponin homology region, an acidic motif, a DAG binding domain, two SH3 regions, and a SH2 domain. VAV3.1 Protein variant contains only the C-terminal SH3-SH2-SH3 region. Regulating the actin cytoskeleton and transcription, VAV3 acts as a GEF on RHOA, RHOG, and RAC1. VAV1, VAV2, and VAV3 respond to similar cell surface receptor tyrosine kinases. VAV3 is rapidly phosphorylated on TCR or EGFR activation. VAV1 and VAV3 enhance NFKB-dependent transcription. Integrin-induced phosphorylation requires SYK. (OMIM, Swiss-Prot, LocusLink, and NCI) (NCI Thesaurus)

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