VEGFR Inhibitor KRN951

An orally bioavailable quinoline-urea derivative inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1 and 2 with potential antiangiogenesis and antineoplastic activities. VEGFR inhibitor KRN951 inhibits VEGF-induced phosphorylation of VEGFRs 1 and 2, which may result in inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and tumor cell death. Expression of VEGFRs may be upregulated in a variety of tumor cell types. (NCI Thesaurus)

YOU MAY ALSO LIKE

VEGFC wt Allele

Human VEGFC wild-type allele is located within 4q34.1-q34.3 and is approximately 109 kb in length. This allele, which encodes vascular endothelial growth…

VEGFC Gene

This gene plays a role in vasculogenesis.

VEGFB wt Allele

Human VEGFB wild-type allele is located in the vicinity of 11q13 and is approximately 4 kb in length. This allele, which encodes…

VEGFB Gene

This gene plays a role in regulation of blood vessel physiology.

VEGFA wt Allele

Human VEGFA wild-type allele is located within 6p12 and is approximately 16 kb in length. This allele, which encodes vascular endothelial growth…

VEGFA Gene

This gene is involved in the regulation of blood vessel growth. It also plays a role as a neurotrophic factor for motor…