VHL-42: 65-76(V74G) Peptide

A peptide vaccine consisting of amino acids 65 through 76 derived from the tumor suppressor protein Von Hippel-Lindau (VHL) with a glycine substitution at position 74. As a cancer vaccine, VHL-59: 65-76(V74G) may stimulate a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing this VHL mutant protein. (NCI Thesaurus)

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Human VHL wild-type allele is located within 3p26-p25 and is approximately 10 kb in length. This allele, which encodes von Hippel-Lindau disease…

VHL syndrome

A rare inherited disorder in which blood vessels grow abnormally in the eyes, brain, spinal cord, adrenal glands, or other parts of…

VHL Gene

This gene is involved in transcriptional repression and protein degradation.

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