Library / English Dictionary

VINCA

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

Periwinkles: low creeping evergreen perennials

Synonyms:

genus Vinca; Vinca

Classified under:

Nouns denoting plants

Hypernyms ("Vinca" is a kind of...):

dicot genus; magnoliopsid genus (genus of flowering plants having two cotyledons (embryonic leaves) in the seed which usually appear at germination)

Meronyms (members of "Vinca"):

periwinkle (chiefly trailing poisonous plants with blue flowers)

Holonyms ("Vinca" is a member of...):

Apocynaceae; dogbane family; family Apocynaceae (chiefly tropical trees or shrubs or herbs having milky juice and often showy flowers; many are sources of drugs)

Credits

 Context examples: 

Upon administration, eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.

(Carbon C 14 Eribulin Acetate, NCI Thesaurus)

Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.

(Eribulin, NCI Thesaurus)

HL-60/MX2 cells are cross-resistant to etoposide, teniposide, bisantrene, dactinomycin, 4'-(9-acridinylamino)methane- sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.

(HL-60/MX2, NCI Thesaurus)

HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.

(HL-60/MX1, NCI Thesaurus)

Any of a class of natural peptides originally isolated from the marine mollusk Dolabella auricularia that bind to tubulin at the vinca/peptide region, thereby inhibiting microtubule assembly and leading to cell cycle arrest and/or apoptosis.

(Dolastatin Compound, NCI Thesaurus)

After ligand-receptor internalization, the vinca alkaloid moiety binds to tubulin and disrupts microtubule assembly-disassembly dynamics, resulting in cell cycle arrest and apoptosis.

(Folate Receptor-Targeted Vinca Alkaloid EC0489, NCI Thesaurus)

Like other vinca alkaloids, vinorelbine may also interfere with the metabolism of nucleic acids, lipids, amino acids, cAMP, and glutathione, as well as other biological processes including calmodulin-dependent Ca2+-transport, ATPase activity, or cellular respiration.

(Liposomal Vinorelbine, NCI Thesaurus)

The relative tumor cell specificity of this agent reduces the toxicity profile of its vinca alkaloid moiety.

(Folate Receptor-Targeted Vinca Alkaloid EC0489, NCI Thesaurus)

A folate receptor-targeting cytotoxic drug conjugate consisting of a folate vitamin analogue linked to a vinca alkaloid microtubule destabilizing agent with potential antineoplastic activity.

(Folate Receptor-Targeted Vinca Alkaloid EC0489, NCI Thesaurus)