| Health / Medical Topics |
Vintafolide
A water-soluble, folate-receptor-targeted conjugate of folate and the vinca alkaloid desacetylvinblastine monohydrazide (DAVLBH) with potential antineoplastic activity. The folate moiety of vintafolide binds to folic acid receptors on the tumor cell surface and the agent is internalized via folate receptor-mediated endocytosis, delivering the tubulin-binding DAVLBH moiety directly into the tumor cell; DAVLBH binding to tubulin results in the disruption of microtubule assembly-disassembly dynamics, cell cycle arrest, and tumor cell apoptosis. Folic acid receptors are frequently upregulated on the surfaces of many tumor cell types. DAVLBH is a derivative of the natural product vinblastine. (NCI Thesaurus)
YOU MAY ALSO LIKE
A regimen consisting of vinorelbine and gemcitabine, used as a salvage regimen for relapsed, childhood Hodgkin's lymphoma following an autologous hematopoietic stem…
A regimen consisting of vinorelbine and epirubicin used for the treatment of metastatic breast cancer.
A regimen consisting of carboplatin and vinorelbine, used to treat advanced-stage non-small lung cancer.
An orally bioavailable tartrate salt of vinorelbine, a semisynthetic vinca alkaloid with potential antineoplastic activity. Vinorelbine binds to tubulin, thereby inhibiting tubulin…
An emulsion containing the tartrate salt of the semisynthetic vinca alkaloid vinorelbine with antineoplastic activity. Vinorelbine binds to tubulin, inhibiting tubulin polymerization…
A drug used to treat advanced non-small cell lung cancer. It blocks cell growth by stopping cell division and may cause cancer…
