Visilizumab

Pronunciation

Definition 1

A monoclonal antibody that binds to CD3 (a substance found on T-cells) and that is being studied as a treatment for graft-versus-host disease (GVHD). It belongs to the family of drugs called monoclonal antibodies. (NCI Dictionary)

Definition 2

A humanized, non-Fc receptor (FcR)-binding IgG2 monoclonal antibody (MoAb) directed against CD3 with potential immunosuppressive activity. Visilizumab binds to invariant CD3 epsilon, one of the non-covalently-associated subunits of T-cell receptors (TCRs) on activated T-cells. Upon binding to the TCR/CD3 complex, visilizumab induces apoptosis, which may result in the selective clonal deletion of activated pathogenic T-cells. This MoAb is engineered with a substitution at amino acid residues 234 and 237 (Val3Ala) within the IgG2 Fc arm, rendering it unable to bind to type II FcRs; accordingly, this agent is less likely to activate type II FcR-expressing resting T-cells. (NCI Thesaurus)

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