Health / Medical Topics

    Volume of Distribution of Fraction Dose Observed Normalized by Weight

    Definition 1

    The observed volume of distribution of the absorbed fraction associated with the terminal slope following extravascular administration, where F equals the fraction of dose absorbed, divided by the weight. (NCI Thesaurus)

    Definition 2

    The volume of distribution associated with the terminal slope following extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration, divided by the weight. (NCI Thesaurus/CDISC)




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