WNT11 Protein

Encoded by human WNT11 Gene (WNT Family), the 354-amino acid 39 kD (precursor) WNT11 protein is expressed in fetal ureteric bud tips, perichondrium, lung mesenchyme, urorectal septum, urogenital folds, labioscrotal swellings, and adrenal cortex as well as adult heart, liver, skeletal muscle, and pancreas. Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. WNT11 may drive vertebrate gastrulation; homolog slb (zebrafish) is required for gastrulation. WNT11 may be required for vertebrate heart formation, mediated by noncanonical WNT-Dishevelled signaling; independent of beta-catenin and involving PKC and JNK. (OMIM, Swiss-Prot, LocusLink, and NCI) (NCI Thesaurus)

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