| Health / Medical Topics |
WNT1 Inducible Signaling Pathway Protein 3
Encoded by human oncogene WISP3 Gene (CCN Family), the 354-amino acid 39.3 kD WNT1 Inducible Signaling Pathway Protein 3 constitutes - with WISP1 and WISP2 - one of three factors downstream in the WNT signaling pathway relevant to malignant transformation. CCN proteins are cell- and tissue-specific cysteine-rich secreted factors with roles in cell growth and differentiation. WISP3 protein is essential for skeletal growth and cartilage homeostasis; mutations are associated with progressive pseudorheumatoid dysplasia. WISP3 is over expressed in colon tumors. (OMIM, Swiss-Prot, LocusLink, and NCI) (NCI Thesaurus)
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