WNT4 Protein

Encoded by human WNT4 Gene, 351-amino acid 39 kD (precursor) WNT4 Protein (WNT Family) is a putative secreted paracrine cysteine-rich glycoprotein ligand for a seven transmembrane frizzled receptor influencing sex-determination. WNT family signaling proteins regulate cell fate and patterning during embryogenesis. WNT4 is similar to mouse and rat proteins Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, and Wnt7b, which contain 83 conserved amino acid residues, including 21 cysteines. Wnt4 is detected in brain, lung, and kidney mesenchyme. Wnt4 appears to be an autoinducer of nephric mesenchyme-to-epithelial transition. WNT4 up regulates DAX1 (antagonizes SRY) controlling female development and preventing testes formation. WNT4, WNT2, and WNT7B may be associated with abnormal proliferation in breast tissue. (from SWISS-PROT, OMIM, and NCI) (NCI Thesaurus)

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WNT4 Gene

This gene plays a role in hormonal signaling and is involved in sex determination.

WNT3 wt Allele

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This gene plays a role in signal transduction and intercellular communication. It is involved in neural development.

WNT2B wt Allele

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WNT2B Protein

Encoded by human oncogene WNT2B Gene (WNT Family), the novel 391-amino acid 43.8 kD (precursor) WNT2B Protein is a homolog of Xenopus…

WNT2B Gene

This gene plays a role in signal transduction and intercellular communication. It is involved in the growth of progenitor cells during…