WNT6 Protein

Encoded by human WNT6 Gene (WNT Family), WNT6 Protein is expressed in brain, testis, placenta, and spleen. In mouse embryos, Wnt6 is expressed panectodermally, in somites, in limb bud, and in the reproductive system. In adult mice, Wnt6 is expressed in the mammary gland. WNT6 encodes a 365-amino acid 39.7 kD (precursor) peptide containing conserved residues, two N-linked glycosylation sites, an N-terminal signal peptide, and an RGD motif. Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. (OMIM, Swiss-Prot, LocusLink, and NCI) (NCI Thesaurus)

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