WNT-3 Protein

Encoded by human WNT3 Gene (WNT Family), 355-amino acid 39.6 kD (precursor) WNT-3 Protein is a wingless (Drosophila) homolog with 98% amino acid identity to mouse Wnt3 protein and 84% to human WNT3A protein. Highly-conserved structurally related WNT proteins are 350-400 amino acid, cysteine-rich, short-range putative paracrine signaling glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. Wnt3 is required in mouse primary axis formation and anterior-posterior neural patterning in the ectoderm. This protein may play a role in some cancers through activation of the WNT-beta-catenin-TCF signaling pathway. (from Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)

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