WT1-A10/AS01B Immunotherapeutic GSK2130579A

An immunotherapeutic consisting of the recombinant fusion protein WT1-A10 combined with the adjuvant ASO1B with potential immunostimulating and antineoplastic activities. Upon administration, WT1-A10/AS01B immunotherapeutic GSK2130579AWT1 may induce a WT1-specific cytotoxic T-lymphocyte (CTL) response against WT1-expressing tumor cells, resulting in cell lysis and the inhibition of cellular proliferation. The tumor-associated antigen WT1 (Wilms tumor protein-1) is overexpressed in most types of leukemia and in a variety of solid cancers. WT1-A10 is a 292 amino acid recombinant fusion protein consisting of a 12-mer truncated tat sequence (leader sequence) and amino acids number 2-281 of the WT1 sequence; ASO1B consists of a combination of the adjuvants monophosporyl lipd A (MPL) and Q21. (NCI Thesaurus)

YOU MAY ALSO LIKE

WT1 wt Allele

Human WT1 wild-type allele is located in the vicinity of 11p13 and is approximately 48 kb in length. This allele, which encodes…

WT1 Peptide Vaccine WT2725

A peptide cancer vaccine comprised of a peptide derived from Wilms tumor gene 1 (WT1) protein, with potential immunomodulating and antineoplastic…

WT1 Peptide Vaccine OCV-501

A peptide cancer vaccine comprised of a peptide derived from Wilms tumor gene 1 (WT1) protein, with potential immunomodulating and antineoplastic…

WT1 mRNA-Electroporated Autologous Dendritic Cell Vaccine

A cancer vaccine containing autologous dendritic cells electroporated with full-length mRNA encoding Wilms' tumor 1 (WT1) antigen with potential immunostimulatory and antineoplastic…

WT1 Gene

This gene plays a role in regulation of transcription. It is involved in the control of both cell differentiation and proliferation. …

WT1 Analog Peptide Vaccine

A peptide vaccine comprised of an epitope of human Wilms tumor 1 (WT-1) with potential antineoplastic activity. WT-1, a transcription factor, is…