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XANTHINE
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I. (noun)
Sense 1
Meaning:
Crystalline oxidation product of the metabolism of nucleoproteins; precursor of uric acid; found in many organs and in urine
Classified under:
Hypernyms ("xanthine" is a kind of...):
organic compound (any compound of carbon and another element or a radical)
Context examples:
A xanthine derivative.
(Dyphylline, NCI Thesaurus)
Classified as bronchodilators (beta-adrenoreceptor agonists, xanthines, muscarinic-receptor antagonists) and anti-inflammatory agents (glucocorticoids, cromolyn), natural or synthetic Anti-asthmatic Agents relieve asthma (a recurrent airway obstruction) in multiple ways and at various sites, by reducing bronchial spasm, dyspnea, allergic reaction, local inflammation, and pain.
(Anti-asthmatic Agent, NCI Thesaurus)
This species is nonmotile, non-spore forming, catalase and urease positive, reduces nitrate, does not produce acid phosphatase, hydrolyzes esculin and testosterone, but not casein, elastin, hypoxanthine, tyrosine, and xanthine, and produces a mycelium and aerial hyphae that fragments into coccoid elements.
(Nocardia farcinica, NCI Thesaurus)
Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis.
(Azathioprine, NCI Thesaurus)
Upon oral administration, febuxostat selectively and noncompetitively inhibits the activity of xanthine oxidase, an enzyme that converts oxypurines, including hypoxanthine and xanthine, into uric acid.
(Febuxostat, NCI Thesaurus)
By inhibiting xanthine oxidase, uric acid production is reduced and serum uric acid levels are lowered.
(Febuxostat, NCI Thesaurus)
