Health / Medical Topics |
Xeroderma Pigmentosum Complementation Group A Protein
DNA-Repair Protein Complementing XP-A Cells (XPA), the nuclear protein encoded by the XPA gene, has a zinc finger domain and is involved in the DNA excision repair pathway. XPA initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. XPA complements the defect in xeroderma pigmentosum (XP) group A (XP-A), an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders. (NCI Thesaurus)
YOU MAY ALSO LIKE
A genetic condition marked by an extreme sensitivity to ultraviolet radiation, including sunlight. People with xeroderma pigmentosum are not able to repair…
A non-neoplastic disorder characterized by abnormally dry skin. Causes include vitamin A deficiency, sunlight exposure, medications, metabolic disorders, autoimmune disorders, and…
A diphenyl ketoaldehyde derivative with broad-spectrum antiviral activity.
A gammaretrovirus that has been isolated from human biological samples and associated with familial and sporadic prostate cancer and chronic fatigue…
A species of South African aquatic frog of the genus Xenopus. It is up to 12 cm long with a flattened head…
Any of various aquatic, tongueless, clawed frogs of the genus Xenopus, native to southern Africa, especially X. laevis, widely used in the…