YXXP Motif

YXXP (tyrosine-X-X-Proline), a substrate sequence preferred by Abl tyrosine kinases, is part of the SH2 domain that mediates certain interactions of SH2 containing proteins. Although both phosphorylated- and unphosphorylated-YXXP can interacts with SH2 containing proteins, the SH2 domain obtain sufficient binding specificity from the recognition of adjacent residues to allow discrimination between different phosphorylated sites. (NCI Thesaurus)

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