Zafirlukast

Pronunciation

Definition 1

A drug used to prevent and treat symptoms of asthma. It blocks substances that cause inflammation in the lungs. It is a type of antiasthmatic agent and a leukotriene receptor antagonist. Also called Accolate. (NCI Dictionary)

Definition 2

A toyl compound with anti-asthmatic property. Zafirlukast selectively and competitively binds and blocks the cysteinyl leukotriene 1 receptor , thereby preventing potent proinflammatory mediators leukotriene C4, D4 and E4 from binding. This prevents leukotriene-mediated actions, including enhanced migration of eosinophils and neutrophils, increased adhesion of leukocytes, increased monocyte and neutrophil aggregation, increased airway edema, inflammation, capillary permeability and bronchoconstriction. (NCI Thesaurus)

YOU MAY ALSO LIKE

Zacatecas

A state in north-central Mexico. Its capital is Zacatecas.

Zabiciprilat

A non-thiol angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Zabiciprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin…

Zabicipril

A non-thiol angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zabicipril is rapidly converted in vivo by de-esterification into its…

Z, Rat Strain

Derived from a spontaneous mutation in the leptin receptor that appeared in a 13M rat colony bred at the Zucker Laboratory of…

Z-Score

Indicates how far and in what direction an item deviates from its distribution's mean, expressed in units of its distribution's standard…

Z-Endoxifen Hydrochloride

The hydrochloride salt and the z (cis-) stereoisomer of endoxifen with potential antineoplastic activity. Endoxifen, the active metabolite of tamoxifen, competitively inhibits…