Zebularine

A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions. (NCI Thesaurus)

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ZEB2 wt Allele

Human ZEB2 wild-type allele is located in the vicinity of 2q22 and is approximately 132 kb in length. This allele, which encodes…

ZEB2 Gene

This gene is involved in regulation of transcription.

ZEB1 wt Allele

Human ZEB1 wild-type allele is located in the vicinity of 10p11.2 and is approximately 214 kb in length. This allele, which encodes…

ZEB1 Gene

This gene is involved in the transcriptional repression of interleukin 2.