Health / Medical Topics |
Zofenopril
A sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zofenopril is hydrolyzed in vivo into its active form zofenoprilat. Zofenoprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zofenoprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. (NCI Thesaurus)
YOU MAY ALSO LIKE
A drug used to lower the amount of cholesterol and other harmful substances in the blood, such as triglycerides. It is also…
Human ZNF703 wild-type allele is located in the vicinity of 8p11.23 and is approximately 3 kb in length. This allele, which encodes…
This gene may play a role in transcriptional regulation.
Human ZNF700 wild-type allele is located in the vicinity of 19p13.2 and is approximately 26 kb in length. This allele, which encodes…
This gene plays a role in the regulation of transcription.
Human ZNF687 wild-type allele is located in the vicinity of 1q21.2 and is approximately 10 kb in length. This allele, which encodes…